The present invention provides a fully automatic anti-flooding protective confinement door, related to the field of tunnel equipment, said protective confinement door is set at the two ends of the tunnel, comprising: a door frame, said door frame is poured on the wall of said tunnel; a door fan, said door fan is hingedly connected to said door frame; a lifting and closing mechanism, said lifting and closing mechanism is connected to said door fan, and said lifting and closing mechanism is capable of sealing the bottom of the door fan and fixing said door fan to said door frame during the process of opening and closing, which is simple in operation and reliable, and there is no need to set a groove at the bottom. When said door is closed, said lifting and closing mechanism is able to seal the bottom of said door and fix said door to said door frame. The present invention provides a fully automatic anti-flooding protection hermetic door that does not need to be lifted and lowered during the opening and closing process of the door, which is simple in operation, reliable and does not need to be equipped with a groove at the bottom. It solves the problem that the flood-proof door of the road tunnel in the existing technology cannot realize the fully automatic operation function.